School officials in Auburn say the Center for Disease Control notified them that two students have confirmed cases of whooping cough.
School staff are now warning parents what to look for in their students to limit the spread of pertussis. Parents were sent a letter and calls alerting them to the cases.
School officials said in a letter that students with confirmed cases should tell the school and should stay home from school and all activities until they have had five days of antibiotics.
Staff say the school underwent additional cleaning to help limit the spread of the disease.
Whooping cough is a highly contagious respiratory disease that was nearly eradicated at one point.
The Maine Department of Health & Human Services says whooping cough, or pertussis, was on the rise in the fall of 2018.
There were 332 pertussis cases reported statewide through the end of October 2018, compared to 349 reported cases in the whole of 2017. The five-year median of whopping cases in Maine is at 251, far below this year's reported cases.